Cyclooxygenase-2–Dependent Prostacyclin Formation and Blood Pressure Homeostasis
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: targeted exchange of cyclooxygenase isoforms in mice.
RATIONALE Cyclooxygenase (COX)-derived prostanoids (PGs) are involved in blood pressure homeostasis. Both traditional nonsteroidal antiinflammatory drugs (NSAIDs) that inhibit COX-1 and COX-2 and NSAIDs designed to be selective for inhibition of COX-2 cause sodium retention and elevate blood pressure. OBJECTIVE To elucidate the role of COX-2 in blood pressure homeostasis using COX-1>COX-2 mic...
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The role of angiotensinogen in blood pressure control was assessed in normotensive rats by observing the changes resulting from inhibition by specific rat angiotensinogen antiserum. The antiserum decreased blood pressure in rats on normal sodium as well as sodium-free diets (respectively delta BP = -30 +/- 6 mm Hg and -42 +/- 8 mm Hg). In binephrectomized sodium-replete rats, administration of ...
متن کاملWater-Electrolyte Balance in Blood Pressure Homeostasis
Water-Electrolyte Balance in Blood Pressure Homeostasis Much of what human life is about is water (60% of body mass) and a handful of solutes. Of the latter, main cations include sodium, potassium, calcium, and magnesium, and the anions include chloride, bicarbonate, phosphate and organic anions, and proteins. The concentrations of sodium (135–145 mmol/L) and chloride (95–106 mmol/L) predominat...
متن کاملWater-Electrolyte Balance in Blood Pressure Homeostasis
Water-Electrolyte Balance in Blood Pressure Homeostasis Much of what human life is about is water (60% of body mass) and a handful of solutes. Of the latter, main cations include sodium, potassium, calcium, and magnesium, and the anions include chloride, bicarbonate, phosphate and organic anions, and proteins. The concentrations of sodium (135–145 mmol/L) and chloride (95–106 mmol/L) predominat...
متن کاملCyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis.
BACKGROUND The formation of prostacyclin (PGI(2)), thromboxane (TX) A(2), and isoprostanes is markedly enhanced in atherosclerosis. We examined the relative contribution of cyclooxygenase (COX)-1 and -2 to the generation of these eicosanoids in patients with atherosclerosis. METHODS AND RESULTS The study population consisted of 42 patients with atherosclerosis who were undergoing surgical rev...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2010
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.109.204529